Mechanisms of Carvedilol Action in Human Congestive Heart Failure
نویسندگان
چکیده
منابع مشابه
Mechanisms of carvedilol action in human congestive heart failure.
The precise mechanism by which beta-adrenoceptor blockers exert their beneficial actions in patients with heart failure remains unclear. Several possibilities have been proposed, including heart rate reduction, beta2-adrenoceptor-mediated modulation of catecholamine release, antagonism of the receptor-mediated toxic actions of norepinephrine on the myocardium, and favorable effects on myocardia...
متن کاملRandomized trial of carvedilol in treatment of congestive heart failure.
BACKGROUND Members of the U.S. Cardevivol Study Group at Lovelace Scientific Resources, Albuquerque, NM, designed and carried out a large multicenter randomized clinical trial of Cardevilol vs placebo in patients with clinical heart failure and ejection fraction < 0.35. RESULTS Derived exposure and death data at 50-day intervals to 400 days were used to construct tables of comparative mortali...
متن کاملCONGESTIVE HEART FAILURE IN CHILDREN: A SURVEY OF 114 PATIENTS
During a period of four years between June, IS, 1988 to June, IS, 1992 one hundred and fourteen patients with congestive heart failure (CHF) were admitted to the pediatric department of Taleghani General Hospital. During the above period, 192 patients with heart disease were hospitalized at this department and CHF was the cause of admission in 59.4% of them. Congenital heart disease (CHO) w...
متن کاملAbnormal Baroreflex Mechanisms in Congestive Heart Failure
P atients with low output congestive heart failure have less-than-normal slowing of heart rate during pharmacologic increases of arterial pressure, indicating impairment of the arterial baroreceptor-heart rate reflex.1 The mechanism underlying this abnormality is not fully understood and could involve one or more components of the reflex arc, including an afferent limb (generation and transmiss...
متن کاملThe Different Mechanisms of Action Potential Propagation in the Heart
It was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. Some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (AP). It seems that some other types of mechanisms must be involved in AP propagation. In this article, we...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2001
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.37.5.1216